type 3 metabotropic glutamate receptor binding

Definition

Target type: molecularfunction

Binding to a type 3 metabotropic glutamate receptor. [GOC:mah, GOC:nln]

Type 3 metabotropic glutamate receptors (mGluR3) are members of the G protein-coupled receptor (GPCR) superfamily, specifically the group III metabotropic glutamate receptors. They are responsible for mediating the effects of glutamate, the primary excitatory neurotransmitter in the central nervous system, through a complex signaling cascade involving G proteins.

mGluR3 binding triggers a series of molecular events that ultimately modulate neuronal activity. Upon glutamate binding to the receptor, a conformational change occurs, leading to the activation of coupled G proteins, specifically Gαi/o proteins. These G proteins then activate downstream signaling pathways, primarily by inhibiting adenylyl cyclase, an enzyme responsible for the production of cyclic AMP (cAMP). The reduction in cAMP levels leads to the suppression of protein kinase A (PKA) activity, a key enzyme involved in various cellular processes.

Furthermore, mGluR3 activation can also activate other intracellular signaling pathways, such as the phospholipase C (PLC) pathway, leading to the production of diacylglycerol (DAG) and inositol trisphosphate (IP3). DAG activates protein kinase C (PKC), while IP3 triggers the release of calcium ions from intracellular stores.

The molecular function of mGluR3 binding is thus characterized by its ability to inhibit cAMP production, modulate calcium signaling, and influence the activity of various protein kinases. These diverse downstream effects contribute to the complex and multifaceted roles of mGluR3 in neuronal function, including synaptic plasticity, neuronal excitability, and neuroprotection.'
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Proteins (1)

Compounds (1)