C5L2 anaphylatoxin chemotactic receptor binding

Definition

Target type: molecularfunction

Binding to a C5L2 anaphylatoxin chemotactic receptor. [GOC:mah, GOC:nln]

C5L2, also known as the anaphylatoxin chemotactic receptor, is a G protein-coupled receptor (GPCR) that plays a crucial role in mediating the immune response to complement activation. Complement activation is a critical part of the innate immune system and involves a cascade of protein interactions that ultimately lead to the formation of the membrane attack complex (MAC), which can lyse pathogens. C5L2 is specifically involved in binding the complement component C5a, a potent chemoattractant and inflammatory mediator. Upon C5a binding, C5L2 undergoes conformational changes that activate downstream signaling pathways. These pathways involve the recruitment and activation of intracellular signaling molecules, such as G proteins, which in turn trigger a cascade of events leading to various cellular responses.

One primary function of C5L2 is to mediate chemotaxis, the directed movement of cells towards a chemical gradient. C5a, upon binding to C5L2, triggers the activation of G proteins, specifically Gi/o proteins. These proteins then activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and inositol triphosphate (IP3). IP3 subsequently mobilizes intracellular calcium, which in turn activates various signaling pathways that promote actin polymerization and cell migration.

Another key function of C5L2 is its role in inflammatory responses. C5a binding to C5L2 can lead to the activation of the mitogen-activated protein kinase (MAPK) pathway, which plays a critical role in regulating gene expression and cell survival. This pathway can promote the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). These cytokines contribute to the development of inflammation by recruiting and activating immune cells, such as neutrophils and macrophages, to the site of infection or injury.

In addition to its roles in chemotaxis and inflammation, C5L2 has also been implicated in other biological processes, including angiogenesis, wound healing, and tumor growth. The precise mechanisms underlying these functions remain under investigation, but likely involve complex interactions with other signaling pathways and cellular processes.

Overall, the binding of C5a to the C5L2 receptor initiates a cascade of signaling events that mediate chemotaxis, inflammation, and other important biological processes. This receptor is a critical component of the immune system, contributing to the elimination of pathogens and the resolution of infection and injury.'
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Proteins (1)

Compounds (1)