Target type: molecularfunction
Binds to and stops, prevents, or reduces the activity of a potassium channel. [GOC:mah]
Potassium channel inhibitors are a class of drugs that block the flow of potassium ions (K+) through potassium channels in cell membranes. These channels are crucial for regulating a wide range of cellular processes, including nerve impulse transmission, muscle contraction, and hormone secretion. Potassium channel inhibitors exert their effects by binding to the channel pore, thereby physically obstructing the passage of potassium ions. This blockage disrupts the normal flow of potassium ions across the membrane, leading to changes in membrane potential and cellular function. The specific effects of potassium channel inhibitors depend on the type of potassium channel targeted, the location of the channel in the body, and the concentration of the inhibitor. For example, some potassium channel inhibitors are used to treat heart arrhythmias, while others are used to relieve pain or treat seizures. Potassium channel inhibitors are an important class of drugs with diverse therapeutic applications. However, their use can also be associated with side effects, such as muscle weakness, fatigue, and dizziness, due to their ability to interfere with essential physiological processes.'
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Protein | Definition | Taxonomy |
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Beta-casein | A beta-casein that is encoded in the genome of cow. [OMA:P02666, PRO:DAN] | Bos taurus (cattle) |
Compound | Definition | Classes | Roles |
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4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione: a GSK3beta inhibitor TDZD-8 : A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. | benzenes; thiadiazolidine | anti-inflammatory agent; antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent |
abt-737 | aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound | anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor |