putrescine binding

Definition

Target type: molecularfunction

Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. [GOC:ai]

Putrescine binding is a molecular function that involves the non-covalent interaction of a protein or other molecule with the polyamine putrescine. Putrescine is a small, positively charged molecule that is essential for a wide range of cellular processes, including cell growth, proliferation, and differentiation. Putrescine binding proteins play a crucial role in regulating these processes by controlling the availability and distribution of putrescine within the cell.

The binding of putrescine to proteins can occur through a variety of mechanisms, including electrostatic interactions, hydrogen bonding, and hydrophobic interactions. The specific amino acid residues involved in putrescine binding vary depending on the protein.

Putrescine binding proteins are involved in a wide range of cellular functions, including:

* **Signal transduction:** Putrescine binding proteins can act as receptors for putrescine, triggering signaling pathways that regulate gene expression and cell behavior.
* **Enzyme activity:** Putrescine binding can modulate the activity of enzymes involved in various metabolic pathways, including polyamine synthesis and degradation.
* **DNA and RNA interactions:** Some putrescine binding proteins interact with DNA and RNA, influencing gene expression and translation.
* **Protein-protein interactions:** Putrescine binding can mediate protein-protein interactions, influencing the formation of protein complexes and cellular organization.

The dysregulation of putrescine binding can lead to a variety of diseases, including cancer, neurological disorders, and cardiovascular disease. Therefore, understanding the molecular function of putrescine binding is crucial for developing new diagnostic and therapeutic strategies for these conditions.'
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Proteins (1)

Compounds (2)