protein-phosphatidylethanolamide deconjugating activity

Definition

Target type: molecularfunction

Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue. [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328]

Protein-phosphatidylethanolamine deconjugating activity refers to the enzymatic process that specifically cleaves the bond between phosphatidylethanolamine (PE) and its conjugated molecule. PE is a phospholipid that plays a crucial role in cell membrane structure and function, and its deconjugation can have significant implications for cellular processes.

The enzyme responsible for this activity is known as a "phosphatidylethanolamine deconjugase" or "PE deconjugase". These enzymes typically belong to the hydrolase family and utilize water molecules to hydrolyze the bond between PE and its conjugate.

The deconjugation of PE can lead to the release of free PE molecules, which can then be incorporated into new membrane structures or used as precursors for other cellular processes. This process can also generate free conjugates that may have their own distinct biological functions.

PE deconjugation is involved in a variety of cellular processes, including:

* **Membrane remodeling**: PE deconjugation can alter the lipid composition of cellular membranes, affecting their fluidity, permeability, and signaling properties.
* **Signal transduction**: Some PE conjugates act as signaling molecules, and their deconjugation can influence the activation or inactivation of downstream signaling pathways.
* **Lipid metabolism**: PE deconjugation can contribute to the regulation of lipid metabolism, including the synthesis and breakdown of lipids.
* **Cellular growth and differentiation**: PE deconjugation has been implicated in processes related to cell growth, proliferation, and differentiation.

The specific molecular function of PE deconjugation can vary depending on the type of conjugate involved, the cellular context, and the specific enzyme catalyzing the reaction. Further research is needed to fully understand the diverse roles of PE deconjugation in cellular biology.'
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Proteins (2)

Compounds (10)