FAT10 activating enzyme activity

Definition

Target type: molecularfunction

Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:mah]

FAT10 activating enzyme activity is a molecular function that describes the ability of an enzyme to activate the protein FAT10. FAT10 is a ubiquitin-like protein that plays a role in the cellular response to stress. Upon activation by the activating enzyme, FAT10 can be conjugated to target proteins through a process similar to ubiquitination. This conjugation can lead to various cellular outcomes, including protein degradation, changes in protein localization, and modulation of protein activity.

The FAT10 activating enzyme catalyzes the formation of a thioester bond between the C-terminal glycine of FAT10 and a cysteine residue in the active site of the enzyme. This process is analogous to the activation of ubiquitin by the E1 ubiquitin activating enzyme. Once activated, FAT10 can then be transferred to a specific E2 conjugating enzyme, which facilitates the conjugation of FAT10 to target proteins.

The molecular function of FAT10 activating enzyme activity is essential for the proper regulation of FAT10-mediated cellular responses. Dysregulation of this activity has been linked to various diseases, including cancer and immune disorders.'
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Proteins (1)

Compounds (1)