Target type: molecularfunction
Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. [GOC:ai]
Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, refers to the enzymatic catalysis of the hydrolysis of amide bonds within linear amide molecules. These enzymes cleave the bond between a carbon atom and a nitrogen atom in a linear amide molecule, resulting in the formation of a carboxylic acid and an amine. This process typically involves the addition of a water molecule across the amide bond, breaking it and releasing the products. The specificity of these enzymes is dictated by the structure of the amide substrate, ensuring that only linear amides are targeted. These enzymes play crucial roles in various metabolic pathways, including the breakdown of proteins, the synthesis of amino acids, and the degradation of xenobiotics.'
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Protein | Definition | Taxonomy |
---|---|---|
Acid ceramidase | An acid ceramidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13510] | Homo sapiens (human) |
Prostate-specific antigen | A prostate-specific antigen that is encoded in the genome of human. [PRO:CNA, UniProtKB:P07288] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
carmofur | organohalogen compound; pyrimidines | ||
2-(n-myristoylamino)-1-phenyl-1-propanol | 2-(N-myristoylamino)-1-phenyl-1-propanol: ceramidase inhibitor; RN given for ((R*,S*)-(+-))-isomer; structure in first source | alkylbenzene | |
n-oleoylethanolamine | N-oleoylethanolamine: ceramidase inhibitor oleoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide. | endocannabinoid; N-(long-chain-acyl)ethanolamine; N-acylethanolamine 18:1 | EC 3.5.1.23 (ceramidase) inhibitor; geroprotector; PPARalpha agonist |
mdv 3100 | (trifluoromethyl)benzenes; benzamides; imidazolidinone; monofluorobenzenes; nitrile; thiocarbonyl compound | androgen antagonist; antineoplastic agent |