DNA translocase activity

Definition

Target type: molecularfunction

Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. [GOC:mah, PMID:16428451, PMID:17631491]

DNA translocase activity refers to the ability of a protein to move along a DNA molecule. This movement is often driven by the hydrolysis of ATP, which provides the energy required for the protein to translocate along the DNA strand. DNA translocases play a crucial role in a wide range of cellular processes, including DNA replication, DNA repair, and chromosome segregation. During DNA replication, DNA translocases are involved in unwinding the DNA double helix, separating the two strands so that they can be copied. In DNA repair, translocases can move along the DNA strand to identify and remove damaged or mutated nucleotides. In chromosome segregation, DNA translocases help to ensure that each daughter cell receives a complete set of chromosomes during cell division. These proteins can move in either direction along the DNA strand, depending on their specific function and the direction of the energy source. Some translocases have a specific directionality, moving only in one direction along the DNA, while others can move in either direction. Additionally, some translocases have the ability to bind and interact with other proteins involved in DNA metabolism, allowing them to coordinate their activities with other cellular processes.'
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Proteins (1)

Compounds (1)