ADP-heptose-lipopolysaccharide heptosyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. [MetaCyc:RXN0-5061]

ADP-heptose-lipopolysaccharide heptosyltransferase activity is a crucial enzyme in the biosynthesis of lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria. This enzyme catalyzes the transfer of a heptose sugar moiety from the donor molecule ADP-heptose to the lipid A core of LPS. Specifically, it adds the first heptose residue to the Kdo2-lipid A disaccharide, initiating the formation of the core oligosaccharide. This step is essential for the proper assembly and integrity of the LPS molecule, which plays a vital role in bacterial survival and pathogenesis. It protects the bacterial cell from various environmental stresses, contributes to cell wall structure and stability, and facilitates interactions with the host immune system. The activity of ADP-heptose-lipopolysaccharide heptosyltransferase is highly conserved among Gram-negative bacteria and is essential for their viability. This enzyme has been recognized as a potential target for antimicrobial drug development, aiming to disrupt LPS synthesis and weaken bacterial resistance.'
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Proteins (1)

Compounds (2)