calcium-dependent protein serine/threonine phosphatase regulator activity
Definition
Target type: molecularfunction
Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. [GOC:ai]
Calcium-dependent protein serine/threonine phosphatase regulator activity is a molecular function that involves the regulation of the activity of protein serine/threonine phosphatases (PSPs). PSPs are enzymes that remove phosphate groups from serine and threonine residues on target proteins, thereby altering their activity and function. Calcium-dependent protein serine/threonine phosphatase regulator activity is essential for a wide range of cellular processes, including signal transduction, cell cycle regulation, and gene expression.
The regulation of PSPs by calcium-dependent regulators occurs through various mechanisms, including:
- Direct binding of calcium ions to the regulator protein, which can induce conformational changes that affect its interaction with the PSP.
- Calcium-dependent phosphorylation or dephosphorylation of the regulator protein, which can modulate its activity.
- Calcium-dependent association of the regulator protein with other signaling molecules, which can influence its interaction with the PSP.
Examples of calcium-dependent protein serine/threonine phosphatase regulator proteins include calcineurin, calmodulin, and protein phosphatase 2B (PP2B). These proteins are involved in a variety of cellular processes, including:
- Regulation of muscle contraction
- Neuronal signaling
- Immune responses
- Cell growth and differentiation
The dysregulation of calcium-dependent protein serine/threonine phosphatase regulator activity can contribute to a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Therefore, understanding the mechanisms of this activity is crucial for developing novel therapies for these conditions.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Calcineurin subunit B type 1 | A calcineurin subunit B type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63098] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cyclosporine | ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF | homodetic cyclic peptide | anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite |