Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. [ISBN:0721662544]
Profilin is a small, ubiquitous actin-binding protein that plays a crucial role in the regulation of actin polymerization. It binds to monomeric actin (G-actin), preventing its spontaneous nucleation and polymerization into filaments. This interaction is critical for controlling the spatiotemporal dynamics of actin assembly, which is essential for a wide range of cellular processes, including cell motility, endocytosis, exocytosis, and signal transduction.
Profilin binding to actin is regulated by several factors, including the concentration of free actin monomers, the presence of other actin-binding proteins, and the phosphorylation state of profilin. The binding of profilin to actin involves a specific interaction between the N-terminal WH2 domain of profilin and the barbed end of actin.
Upon binding, profilin alters the conformation of actin, making it more susceptible to addition to the barbed end of an existing filament. This allows profilin to act as a "molecular shuttle," delivering actin monomers to the barbed end of actin filaments and promoting their elongation. In addition to its role in actin polymerization, profilin can also interact with other proteins, including polyphosphoinositides, myosin, and various signaling molecules. These interactions further contribute to the complex regulatory network that controls actin dynamics and cell function.
Profilin binding to actin is a highly dynamic process that is constantly regulated by cellular signals. The interplay between profilin and actin is essential for maintaining the structural integrity and functional versatility of the actin cytoskeleton, which is a critical component of all eukaryotic cells.'
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| Compound | Definition | Classes | Roles |
|---|
| SMER 28 | SMER 28 : A member of the class of quinazolines that is quinazoline which is substituted by a prop-2-en-1-ylnitrilo group and a bromo group at positions 4 and 6, respectively. It is a modulator of mammalian autophagy. | organobromine compound;
quinazolines;
secondary amino compound | autophagy inducer |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-phenylthieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(4-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[2-[(6-chloro-4-quinazolinyl)amino]ethyl]phenol | | quinazolines | |
| 5-(4-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(4-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(2-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(3-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(3-fluorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(2-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(3-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(2-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]benzonitrile | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-(4-nitrophenyl)thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-(4-phenylphenyl)thieno[2,3-d]pyrimidine | | biphenyls;
thienopyrimidine | |
| 5-(1,3-benzodioxol-5-yl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-(3-thiophenyl)thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(2-benzofuranyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-(4-dibenzothiophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | dibenzothiophenes;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 1-[2-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]phenyl]ethanone | | aromatic ketone;
thienopyrimidine | |
| 5-(3-methylsulfonylphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 4-[(1-methyl-5-tetrazolyl)thio]-5-(1-naphthalenyl)thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 5-bromo-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine | | aryl sulfide;
thienopyrimidine | |
| 1-[3-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]phenyl]ethanone | | aromatic ketone;
thienopyrimidine | |