creatine:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in). [TC:2.A.22.3.4]

Creatine:sodium symporter activity refers to the transmembrane transport of both creatine and sodium ions across a cell membrane. This process is crucial for maintaining cellular energy levels, particularly in muscle tissue. The symporter protein facilitates the simultaneous movement of both creatine and sodium ions in the same direction, typically from the extracellular space into the cell. The driving force for this coupled transport is the electrochemical gradient of sodium ions. As sodium ions move down their concentration gradient, they provide the energy needed to move creatine against its concentration gradient. This mechanism allows cells to accumulate creatine against its concentration gradient, ensuring a constant supply of this crucial molecule for energy production. The activity of creatine:sodium symporters is essential for maintaining adequate levels of intracellular creatine, which is then used by the enzyme creatine kinase to generate ATP, the primary energy currency of cells. This activity is particularly important in muscle tissue, where high levels of creatine are required for muscle contraction and energy production.'
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Proteins (2)

Compounds (1)