intracellularly cyclic nucleotide-activated monoatomic cation channel activity

Definition

Target type: molecularfunction

Enables the transmembrane transfer of a monoatomic cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]

Intracellularly cyclic nucleotide-activated monoatomic cation channel activity refers to the function of certain transmembrane proteins that act as channels for the movement of single-atom cations across the cell membrane. These channels are activated by the binding of cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) or cyclic guanosine monophosphate (cGMP), to specific binding sites within the channel protein. This binding event triggers a conformational change in the protein, opening the channel and allowing the passage of specific cations, typically sodium (Na+), potassium (K+), or calcium (Ca2+). The precise mechanism of activation can vary depending on the specific channel protein, but generally involves the binding of the cyclic nucleotide to a specific domain of the channel protein, which then interacts with other domains to open the channel pore. These channels are essential for a wide range of cellular processes, including signal transduction, neurotransmission, muscle contraction, and ion homeostasis. They play critical roles in mediating cellular responses to hormones, neurotransmitters, and other stimuli. By controlling the flow of ions across the membrane, these channels regulate membrane potential, intracellular signaling pathways, and the activity of various cellular processes.'
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Proteins (1)

Compounds (1)