interleukin-5 receptor binding

Definition

Target type: molecularfunction

Binding to an interleukin-5 receptor. [GOC:ai]

Interleukin-5 receptor (IL-5R) binding is a crucial step in the activation and proliferation of eosinophils, a type of white blood cell that plays a vital role in allergic responses, parasitic infections, and tissue remodeling. The IL-5R is a heterodimer composed of two subunits: the alpha subunit (IL-5Rα) and the beta subunit (βc). IL-5, a cytokine produced by T helper cells, binds specifically to the IL-5Rα subunit, initiating a signaling cascade that involves the recruitment and activation of intracellular signaling molecules. Upon IL-5 binding, the IL-5Rα subunit undergoes a conformational change, bringing the βc subunit into close proximity. This interaction triggers the phosphorylation of tyrosine residues within the βc subunit, leading to the activation of downstream signaling pathways, such as the JAK-STAT and PI3K pathways. Activation of these pathways ultimately results in the transcription of genes involved in eosinophil survival, proliferation, differentiation, and effector function. The binding of IL-5 to its receptor is essential for the development and maintenance of eosinophil populations, which are involved in various physiological and pathological processes. Therefore, understanding the molecular function of IL-5R binding is crucial for developing therapeutic strategies to modulate eosinophil responses in allergic diseases, asthma, and other inflammatory conditions.'
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Proteins (1)

Compounds (1)