oncostatin-M receptor activity

Definition

Target type: molecularfunction

Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]

Oncostatin-M receptor activity represents the molecular function of a specific protein receptor that binds to the cytokine oncostatin M (OSM). OSM is a pleiotropic cytokine, meaning it has diverse effects on various cells and tissues, and its activity is mediated through the OSM receptor (OSMR). The OSMR is a heterodimer composed of the glycoprotein 130 (gp130) and the OSM receptor beta subunit (OSMRβ). This receptor complex triggers downstream signaling pathways primarily through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway.

The molecular function of OSMR activity involves several key steps:

1. **Ligand Binding:** OSM, a member of the IL-6 family of cytokines, binds to the OSMRβ subunit, initiating the receptor activation process.
2. **Receptor Dimerization:** Binding of OSM to OSMRβ induces dimerization of the OSMR complex, bringing together gp130 and OSMRβ. This dimerization is crucial for the activation of downstream signaling pathways.
3. **JAK Activation:** Dimerization of the OSMR complex brings the associated JAK kinases (JAK1 and JAK2) into close proximity, facilitating their activation through phosphorylation.
4. **STAT Phosphorylation:** Activated JAK kinases phosphorylate STAT3, a transcription factor, enabling its dimerization and translocation into the nucleus.
5. **Gene Transcription:** Dimerized and phosphorylated STAT3 binds to specific DNA sequences, activating the transcription of target genes involved in diverse cellular processes, including cell growth, differentiation, inflammation, and immune responses.

Overall, the molecular function of oncostatin-M receptor activity plays a crucial role in mediating the pleiotropic effects of OSM, impacting a wide range of biological processes, including immune regulation, inflammation, and tissue development.'
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Proteins (1)

Compounds (2)