interleukin-11 receptor activity

Definition

Target type: molecularfunction

Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Interleukin-11 receptor activity is a molecular function that describes the ability of a protein to bind interleukin-11 (IL-11), a pleiotropic cytokine involved in various biological processes including hematopoiesis, inflammation, and tissue repair. The IL-11 receptor is a heterodimer composed of two subunits: the IL-11 receptor alpha chain (IL-11Rα) and the glycoprotein 130 (gp130). IL-11 binds specifically to the IL-11Rα subunit, which then recruits gp130 to form the active signaling complex. Upon IL-11 binding, the complex undergoes conformational changes that trigger intracellular signaling pathways, primarily the JAK/STAT pathway. The activation of this pathway leads to the transcription of genes involved in cell proliferation, differentiation, and survival. In addition to its role in hematopoiesis, IL-11 signaling has been implicated in other processes such as osteoblast differentiation, chondrocyte proliferation, and wound healing. The precise molecular mechanisms underlying these diverse functions are still being investigated, but it is clear that IL-11 receptor activity plays a crucial role in regulating a wide range of biological processes. '
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Proteins (1)

Compounds (2)