Page last updated: 2024-10-24

interleukin-6 receptor activity

Definition

Target type: molecularfunction

Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Interleukin-6 receptor (IL-6R) activity is a critical component of the IL-6 signaling pathway, which plays a diverse role in immune responses, inflammation, and cellular proliferation. IL-6R, a transmembrane protein, binds to interleukin-6 (IL-6), a pleiotropic cytokine, initiating a cascade of intracellular events. This interaction triggers the association of IL-6R with gp130, a shared signal transducer for several cytokines. This complex activates the Janus kinase (JAK) family of tyrosine kinases, which phosphorylate and activate signal transducer and activator of transcription 3 (STAT3). Phosphorylated STAT3 dimerizes and translocates to the nucleus, where it regulates the transcription of various genes involved in inflammation, immune responses, and cell growth. Notably, IL-6R activity is essential for the development of acute-phase response, a protective mechanism against infection and injury. It also plays a crucial role in antibody production by B cells and the differentiation of T cells. However, aberrant IL-6 signaling has been implicated in chronic inflammatory diseases, autoimmune disorders, and cancer development. Therefore, modulating IL-6R activity holds therapeutic potential for these conditions.'
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Proteins (1)

ProteinDefinitionTaxonomy
Interleukin-6 receptor subunit betaAn interleukin-6 receptor subunit beta that is encoded in the genome of human. [PRO:WCB, UniProtKB:P40189]Homo sapiens (human)

Compounds (2)

CompoundDefinitionClassesRoles
madindoline amadindoline A: inhibits interleukin-6; isolated from Streptomyces; structure in first source
lmt-28LMT-28: an interleukin-6 inhibitor that binds gp130; structure in first source