interleukin-6 receptor activity

Definition

Target type: molecularfunction

Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Interleukin-6 receptor (IL-6R) activity is a critical component of the IL-6 signaling pathway, which plays a diverse role in immune responses, inflammation, and cellular proliferation. IL-6R, a transmembrane protein, binds to interleukin-6 (IL-6), a pleiotropic cytokine, initiating a cascade of intracellular events. This interaction triggers the association of IL-6R with gp130, a shared signal transducer for several cytokines. This complex activates the Janus kinase (JAK) family of tyrosine kinases, which phosphorylate and activate signal transducer and activator of transcription 3 (STAT3). Phosphorylated STAT3 dimerizes and translocates to the nucleus, where it regulates the transcription of various genes involved in inflammation, immune responses, and cell growth. Notably, IL-6R activity is essential for the development of acute-phase response, a protective mechanism against infection and injury. It also plays a crucial role in antibody production by B cells and the differentiation of T cells. However, aberrant IL-6 signaling has been implicated in chronic inflammatory diseases, autoimmune disorders, and cancer development. Therefore, modulating IL-6R activity holds therapeutic potential for these conditions.'
"

Proteins (1)

Compounds (2)