mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). [EC:3.2.1.114]

Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity is a catalytic activity that involves the hydrolysis of alpha-1,3- and alpha-1,6-linked mannose residues from the non-reducing end of mannosyl-oligosaccharides. This activity is crucial for the processing of N-linked glycans during glycoprotein biosynthesis. Specifically, it is involved in the removal of terminal mannose residues from the Man9GlcNAc2 precursor, which is a key step in the conversion of high-mannose oligosaccharides to complex N-glycans. The enzyme responsible for this activity is called mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, also known as mannosidase I. This enzyme plays a critical role in the formation of a diverse array of N-glycans, which contribute to protein folding, stability, and interactions with other molecules.'
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Proteins (1)

Compounds (1)