homoserine kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. [EC:2.7.1.39, RHEA:13985]

Homoserine kinase activity is a critical enzymatic process involved in the biosynthesis of methionine and threonine, two essential amino acids. This activity catalyzes the phosphorylation of L-homoserine, a crucial intermediate in the biosynthesis pathway, using ATP as the phosphate donor. The resulting product, O-phospho-L-homoserine, is then further metabolized to ultimately yield methionine and threonine. This enzymatic reaction is highly specific, requiring the presence of L-homoserine as the substrate and ATP as the phosphoryl donor. The enzyme responsible for homoserine kinase activity is known as homoserine kinase, which is encoded by the THRK gene in humans. This enzyme typically resides in the cytoplasm of the cell and plays a vital role in cellular metabolism and the production of essential amino acids. Homoserine kinase activity is tightly regulated by various factors, including substrate availability, product accumulation, and cellular energy status. The regulation of this activity is crucial for maintaining proper amino acid levels and supporting cellular growth and function.'
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Proteins (1)

Compounds (1)