Target type: molecularfunction
Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. [EC:1.4.1.4]
Glutamate dehydrogenase (NADP+) catalyzes the reversible oxidative deamination of L-glutamate to α-ketoglutarate, using NADP+ as an electron acceptor. This reaction is crucial in the metabolism of amino acids, particularly in the nitrogen cycle, as it links amino acid metabolism to the citric acid cycle. The enzyme plays a vital role in ammonia assimilation and detoxification, converting ammonia to glutamate, a key amino acid used for protein synthesis and other metabolic processes. Furthermore, glutamate dehydrogenase (NADP+) contributes to the regulation of redox balance, NADPH production, and energy metabolism. It participates in gluconeogenesis by providing α-ketoglutarate, a precursor for glucose synthesis. The enzyme's activity is influenced by various factors, including allosteric regulation by ADP, GTP, and NADPH, and substrate concentration. Its localization within the mitochondria allows it to efficiently connect with other metabolic pathways.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| Glutamate dehydrogenase 1, mitochondrial | [no definition available] | Bos taurus (cattle) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nad | NAD | geroprotector | |
| nicotinamide mononucleotide | Nicotinamide Mononucleotide: 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. | nicotinamide mononucleotide | Escherichia coli metabolite; mouse metabolite |
| tiazofurin | tiazofurin: RN given refers to (beta-D)-isomer; structure given in first source tiazofurine : A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase). | 1,3-thiazoles; C-glycosyl compound; monocarboxylic acid amide | antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; prodrug |