Target type: molecularfunction
Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. [EC:1.4.1.2]
Glutamate dehydrogenase (NAD+) activity catalyzes the reversible oxidative deamination of L-glutamate to α-ketoglutarate, using NAD+ as an electron acceptor. This reaction is essential for the metabolism of glutamate, a major excitatory neurotransmitter in the central nervous system. It plays a crucial role in the regulation of ammonia levels in the body, and is involved in the interconversion of amino acids and carbohydrates. The enzyme is also involved in the synthesis of glutamate, a precursor of glutamine, which is important for neurotransmission and detoxification. The activity of glutamate dehydrogenase is regulated by several factors, including allosteric regulation by ADP, GTP, and NADH, as well as by the levels of substrates and products. This complex regulatory system ensures that the enzyme operates efficiently and effectively in response to the needs of the cell.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Glutamate dehydrogenase 1, mitochondrial | [no definition available] | Bos taurus (cattle) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nad | NAD | geroprotector | |
| nicotinamide mononucleotide | Nicotinamide Mononucleotide: 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. | nicotinamide mononucleotide | Escherichia coli metabolite; mouse metabolite |
| tiazofurin | tiazofurin: RN given refers to (beta-D)-isomer; structure given in first source tiazofurine : A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase). | 1,3-thiazoles; C-glycosyl compound; monocarboxylic acid amide | antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; prodrug |