Target type: molecularfunction
Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H+. [EC:2.7.2.11, RHEA:14877]
Glutamate 5-kinase activity is a biochemical process that involves the phosphorylation of glutamate at the 5-position. This reaction is catalyzed by the enzyme glutamate 5-kinase, which utilizes ATP as a phosphate donor. The resulting product, 5-phospho-L-glutamate, serves as a crucial intermediate in the biosynthesis of L-glutamine, an essential amino acid involved in numerous metabolic processes. Glutamate 5-kinase activity is specifically involved in the conversion of glutamate to glutamine, a reaction that is critical for maintaining nitrogen balance and ammonia detoxification in organisms. The enzyme also plays a vital role in the regulation of cellular glutamate levels, which are critical for neurotransmission and other cellular functions. Furthermore, glutamate 5-kinase activity has been implicated in the regulation of cell growth and proliferation. In addition to its role in glutamate metabolism, glutamate 5-kinase activity is also involved in the synthesis of other important molecules, such as glutathione. Glutathione is a potent antioxidant that protects cells from oxidative stress. Glutamate 5-kinase activity is therefore a critical enzyme in various cellular processes, including amino acid metabolism, nitrogen balance, neurotransmission, cell growth, and oxidative stress defense.'
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Protein | Definition | Taxonomy |
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Glutamate 5-kinase | A glutamate 5-kinase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A7B5] | Escherichia coli K-12 |
Compound | Definition | Classes | Roles |
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proline | proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. | amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid | algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite |