aspartate carbamoyltransferase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. [EC:2.1.3.2, RHEA:20013]
Aspartate carbamoyltransferase (ATCase) is a key enzyme in the biosynthesis of pyrimidine nucleotides. It catalyzes the first committed step in the pathway, the condensation of carbamoyl phosphate and L-aspartate to form N-carbamoyl-L-aspartate. This reaction involves the transfer of the carbamoyl group from carbamoyl phosphate to the amino group of aspartate, forming a new carbon-nitrogen bond. The enzyme utilizes a complex mechanism involving multiple active sites, substrate binding, and conformational changes. ATCase is a highly regulated enzyme, with its activity being influenced by the levels of substrates, products, and allosteric effectors. These regulatory mechanisms ensure the efficient and coordinated production of pyrimidine nucleotides, which are essential building blocks for DNA, RNA, and other important cellular components.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| CAD protein | A multifunctional protein CAD that is encoded in the genome of human. [PRO:DNx, UniProtKB:P27708] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| ureidosuccinic acid | N-carbamoylaspartic acid : An N-carbamoylamino acid that is aspartic acid with one of its amino hydrogens replaced by a carbamoyl group. ureidosuccinic acid: RN given refers to (DL)-isomer | aspartic acid derivative; C4-dicarboxylic acid; N-carbamoyl-amino acid | Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite |