adenylosuccinate synthase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H+ + phosphate. [EC:6.3.4.4, RHEA:15753]
Adenylosuccinate synthase (ADSS) catalyzes the reversible conversion of IMP (inosine monophosphate) and aspartate to adenylosuccinate. This reaction is a key step in the de novo biosynthesis of AMP (adenosine monophosphate), a crucial purine nucleotide. ADSS is a bifunctional enzyme that also exhibits adenylosuccinate lyase activity. The mechanism involves two steps: 1) Aspartate reacts with IMP to form an adenylosuccinate intermediate. 2) The intermediate is then cleaved by the lyase activity of ADSS to produce AMP and fumarate. This activity is essential for maintaining purine nucleotide pools and is critical for various cellular processes including DNA replication, RNA transcription, protein synthesis, and energy metabolism.'
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Adenylosuccinate synthetase isozyme 2 | An adenylosuccinate synthetase isozyme 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30520] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| hadacidin | hadacidin : A monocarboxylic acid that is N-hydroxyglycine in which the hydrogen attached to the nitrogen is replaced by a formyl group. It was originally isolated from cultures of Penicillium frequentans. hadacidin: inhibitor of AMP synthesis; RN given refers to parent cpd; structure | aldehyde; monocarboxylic acid; N-hydroxy-alpha-amino-acid | antimicrobial agent; antineoplastic agent; Penicillium metabolite; teratogenic agent |