3-hydroxyacyl-CoA dehydrogenase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. [EC:1.1.1.35]

3-Hydroxyacyl-CoA dehydrogenase activity is a critical enzyme in the beta-oxidation pathway, responsible for the breakdown of fatty acids into energy. This enzyme catalyzes the oxidation of 3-hydroxyacyl-CoA to 3-ketoacyl-CoA, a key step in the process. The enzyme utilizes NAD+ as an electron acceptor, which is reduced to NADH during the reaction. The reaction involves the removal of two hydrogen atoms from the beta-carbon of the 3-hydroxyacyl-CoA molecule, leading to the formation of a carbonyl group at the beta-position. This oxidation step is crucial for the subsequent steps in beta-oxidation, including thiolysis and the release of acetyl-CoA. The 3-hydroxyacyl-CoA dehydrogenase activity is highly specific for the 3-hydroxyacyl-CoA substrate, ensuring that the beta-oxidation pathway proceeds in a controlled and efficient manner. This enzyme is a vital component of the energy metabolism in eukaryotic cells, particularly in the mitochondria, where the beta-oxidation pathway primarily occurs.'
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Proteins (1)

Compounds (1)