3-dehydroquinate synthase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. [EC:4.2.3.4, RHEA:21968]

3-Dehydroquinate synthase (DHQS) catalyzes the sixth step in the shikimate pathway, a crucial metabolic route for the biosynthesis of aromatic amino acids, vitamins, and other essential compounds in bacteria, fungi, plants, and some protozoa. This step involves the conversion of 3-dehydroquinate (DHQ) to 3-dehydroshikimate (DHS). The reaction mechanism involves a complex series of steps, including the abstraction of a proton from the C-6 position of DHQ, followed by an elimination of water to generate a highly reactive intermediate. This intermediate is then stabilized by the formation of a covalent adduct with the enzyme's active site. Finally, the enzyme releases the product, DHS, and regenerates its active form. The active site of DHQS typically contains a tightly bound NADPH cofactor, which is essential for the catalytic activity of the enzyme. DHQS exhibits a high degree of specificity for DHQ as its substrate and its catalytic activity is regulated by various factors including pH, temperature, and the concentration of cofactors and substrate. This enzyme plays a critical role in the biosynthesis of aromatic compounds and is a potential target for the development of novel antibacterial and antifungal agents.'
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Proteins (1)

Compounds (2)