beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. [EC:2.4.1.38]

Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity is a crucial enzyme in the synthesis of N-glycans, complex sugar chains that decorate proteins. This enzymatic activity transfers a galactose residue from UDP-galactose to the terminal N-acetylglucosamine (GlcNAc) of a N-glycan chain, specifically forming a beta-1,4 linkage. This transfer is essential for the elongation of N-glycans, leading to the formation of complex and hybrid types of N-glycans. The enzyme's activity is highly specific, requiring a N-acetylglucosamine residue in the beta-1,2 position of the penultimate mannose residue in the N-glycan core structure, as well as a suitable acceptor protein. The specific glycoproteins targeted by this enzyme vary depending on the organism and cell type, but they often play roles in cell adhesion, recognition, and signaling. This enzyme is involved in a wide range of biological processes, including protein folding, cell differentiation, and immune responses. Deficiencies in this enzyme can lead to various diseases, highlighting its critical role in maintaining cellular function.'
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Proteins (1)

Compounds (1)