peptide receptor activity

Definition

Target type: molecularfunction

Combining with an extracellular or intracellular peptide to initiate a change in cell activity. [GOC:jl]

Peptide receptor activity involves the recognition and binding of specific peptide ligands, leading to signal transduction pathways within the cell. These receptors are typically transmembrane proteins with an extracellular domain that binds the peptide ligand and an intracellular domain that interacts with signaling molecules. Upon ligand binding, the receptor undergoes conformational changes, triggering a cascade of events that ultimately alter cellular processes. The molecular mechanisms underlying peptide receptor activity vary depending on the specific receptor and signaling pathway involved. In some cases, ligand binding activates intracellular enzymes, such as kinases, which phosphorylate target proteins and initiate downstream signaling events. In other cases, receptor activation leads to the production of second messengers, such as cAMP or calcium ions, which propagate the signal within the cell. Peptide receptor activity plays a crucial role in a wide range of physiological functions, including hormone signaling, neurotransmission, immune responses, and cell growth and development. Dysregulation of peptide receptor activity can contribute to various diseases, including cancer, autoimmune disorders, and neurological conditions.'
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Proteins (1)

Compounds (3)