inositol hexakisphosphate binding
Definition
Target type: molecularfunction
Binding to inositol hexakisphosphate. [GOC:go_curators]
Inositol hexakisphosphate (InsP6), also known as phytic acid, is a highly phosphorylated inositol derivative that plays a diverse range of roles in cellular processes. Its molecular function is primarily centered around its ability to bind to proteins, acting as a signaling molecule and modulator of protein activity.
InsP6 binding to proteins can influence their activity in several ways:
1. **Allosteric Regulation:** InsP6 can bind to regulatory sites on proteins, inducing conformational changes that alter their catalytic activity. For instance, InsP6 can activate or inhibit enzymes involved in metabolism, signaling pathways, and gene expression.
2. **Protein-Protein Interactions:** InsP6 can act as a bridge, facilitating interactions between proteins and influencing the formation of protein complexes. This can modulate signaling pathways, control protein localization, and regulate cellular processes.
3. **Protein Stability:** InsP6 can contribute to the stability of proteins by binding to specific regions and preventing their degradation or aggregation. This can be crucial for maintaining proper protein function and cellular integrity.
The specific effects of InsP6 binding are highly context-dependent and vary depending on the protein it interacts with.
Furthermore, InsP6 has been shown to interact with various cellular components, including:
* **DNA and RNA:** InsP6 can bind to nucleic acids, influencing their structure and function. This can impact processes like transcription, translation, and DNA repair.
* **Membrane lipids:** InsP6 can interact with phospholipids in cell membranes, potentially affecting membrane fluidity and signaling.
* **Calcium:** InsP6 can bind to calcium ions, contributing to calcium signaling and cellular homeostasis.
In summary, InsP6 binding is a multifaceted process with profound implications for cellular function. Its ability to interact with diverse proteins and cellular components underscores its crucial role in regulating a wide range of biological processes.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Inositol 1,4,5-trisphosphate receptor type 3 | An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573] | Homo sapiens (human) |
Compounds (1)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| inositol 1,4,5-trisphosphate | Inositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. | myo-inositol trisphosphate | mouse metabolite |