acyl binding

Definition

Target type: molecularfunction

Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. [GOC:curators, ISBN:0198506732]

Acyl binding is a molecular function that involves the non-covalent interaction of a protein or other molecule with an acyl group, which is a functional group consisting of a carbon atom double-bonded to an oxygen atom and single-bonded to an alkyl or aryl group. Acyl groups are present in a wide variety of molecules, including fatty acids, lipids, and certain amino acids.

Acyl binding is often mediated by specific amino acid residues within the protein, which can form hydrogen bonds, electrostatic interactions, or hydrophobic interactions with the acyl group. The specific residues involved in acyl binding can vary depending on the protein and the nature of the acyl group.

Acyl binding plays a crucial role in a variety of cellular processes, including:

* **Lipid metabolism:** Acyl binding proteins are involved in the transport, storage, and metabolism of fatty acids and other lipids.
* **Signal transduction:** Acyl binding can modulate the activity of signaling proteins by altering their conformation or interactions with other molecules.
* **Enzyme catalysis:** Acyl binding is essential for the activity of many enzymes, including those involved in fatty acid synthesis, degradation, and modification.
* **Protein folding and stability:** Acyl binding can contribute to the folding and stability of proteins by promoting hydrophobic interactions and reducing the entropy of the unfolded state.

The specific function of acyl binding proteins is highly dependent on the context in which they are found. For example, acyl binding proteins involved in lipid metabolism often have different structures and functions than those involved in signal transduction or enzyme catalysis.

Overall, acyl binding is a fundamental molecular function that plays a critical role in a wide variety of cellular processes. Understanding the mechanisms of acyl binding is essential for understanding the behavior of proteins and other molecules involved in these processes.'
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Proteins (1)

Compounds (2)