growth cone filopodium

Definition

Target type: cellularcomponent

A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. [PMID:25598228]

Growth cone filopodia are thin, finger-like projections that extend from the leading edge of a growing axon. They play a critical role in guiding the axon towards its target during development. Filopodia are highly dynamic structures, constantly extending and retracting, exploring the environment for guidance cues. They are composed of a core of bundled actin filaments that are cross-linked by a variety of actin-binding proteins. The actin cytoskeleton provides the structural support for the filopodium and is responsible for its shape and motility. The plasma membrane of the filopodium is enriched in various receptors that bind to extracellular guidance cues. These receptors are linked to the actin cytoskeleton by signaling pathways that transduce signals from the environment to the cytoskeleton, regulating filopodial dynamics and growth cone turning. Filopodia also contain other cellular components such as microtubules, which are thought to play a role in transporting materials to the filopodial tip. Finally, filopodia may contain adhesion molecules that help to anchor the growth cone to the extracellular matrix, providing traction for forward movement.'
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Proteins (1)

Compounds (1)