ATF4-CREB1 transcription factor complex
Definition
Target type: cellularcomponent
Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway. [GOC:bhm, PMID:12871976]
The ATF4-CREB1 transcription factor complex is a heterodimer that plays a crucial role in cellular stress response and gene regulation. The complex assembles on the promoter regions of target genes, where it activates transcription. The cellular component of this complex can be described as follows:
* **ATF4 (Activating Transcription Factor 4):** This protein is a key player in the unfolded protein response (UPR), a cellular mechanism that helps restore protein homeostasis in response to stress. ATF4 is a transcription factor that binds to the cAMP response element (CRE) in the promoter regions of target genes. It is localized in the nucleus and can be found associated with chromatin, where it interacts with other transcription factors and regulatory elements.
* **CREB1 (cAMP response element-binding protein 1):** This protein is a ubiquitous transcription factor that plays a role in various cellular processes, including neuronal plasticity, memory formation, and stress response. CREB1 is also a nuclear protein and binds to the CRE. It is often found in association with other proteins, including co-activators and co-repressors, which influence its activity and target gene specificity.
The interaction between ATF4 and CREB1 on the CRE site is essential for the formation of the active transcription factor complex. This complex can then recruit other proteins, such as histone modifying enzymes and co-activators, to the promoter region, leading to increased gene expression. The cellular component of the ATF4-CREB1 complex is therefore characterized by the dynamic interaction of these proteins within the nuclear environment, specifically at the chromatin level, where they regulate gene expression.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Cyclic AMP-dependent transcription factor ATF-1 | A cyclic AMP-dependent transcription factor ATF-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P18846] | Homo sapiens (human) |
| Cyclic AMP-responsive element-binding protein 1 | A cyclic AMP-responsive element-binding protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16220] | Homo sapiens (human) |
Compounds (3)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| baicalein | trihydroxyflavone | angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger | |
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one: isolated from the Chinese herb Scutellariae radix oroxylin A : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. | dihydroxyflavone; monomethoxyflavone | antineoplastic agent; EC 1.14.13.39 (nitric oxide synthase) inhibitor |
| sp 100030 | N-(3,5-bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide: transcription factor inhibitor specific to T-cells |