RPAP3/R2TP/prefoldin-like complex

Definition

Target type: cellularcomponent

A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]

The RPAP3/R2TP/prefoldin-like complex is a multi-protein chaperone complex involved in the biogenesis of a diverse range of cellular components, including ribosomal subunits, RNA polymerase II, and other proteins. It plays a crucial role in the proper folding and assembly of these components, ensuring their functional integrity. The complex consists of multiple subunits:

* **RPAP3 (R2TP complex-associated protein 3)**: A key component of the complex, RPAP3 acts as a scaffold protein, mediating the interaction of other subunits and contributing to the complex's stability.
* **R2TP complex subunits (RUVBL1/RUVBL2, PIH1D1, and TAH1L)**: These subunits, together with RPAP3, form the core R2TP complex. RUVBL1/RUVBL2 are AAA+ ATPases that provide the energy for the complex's chaperone activity. PIH1D1 acts as a scaffold and facilitates the interaction of the complex with its substrates. TAH1L is a WD40 repeat protein that enhances the activity of R2TP.
* **Prefoldin-like subunits (PFDN1, PFDN2, PFDN3, PFDN4, PFDN5, and PFDN6)**: These subunits, also known as the prefoldin complex, contribute to the complex's ability to interact with and stabilize unfolded substrates.

The RPAP3/R2TP/prefoldin-like complex operates in the cytoplasm and the nucleus, where it interacts with its substrates, facilitating their folding and assembly. The complex has been implicated in a wide range of cellular processes, including ribosome biogenesis, RNA polymerase II transcription, protein trafficking, and DNA repair.
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Proteins (2)

Compounds (3)