endoribonuclease complex

Definition

Target type: cellularcomponent

A protein complex which is capable of endoribonuclease activity. [GOC:bhm, GOC:TermGenie, PMID:18191223]

Endoribonuclease complexes are intricate assemblies of proteins that play critical roles in RNA metabolism. These complexes are responsible for the precise degradation and processing of RNA molecules, ensuring proper gene expression and cellular function. Their cellular component is highly dynamic and varies depending on the specific endoribonuclease involved and its cellular function.

Here's a detailed breakdown of the key components and their roles:

1. **Endoribonucleases:** These enzymes are the core of the complex, directly responsible for cleaving RNA molecules at specific sites. Different endoribonucleases exhibit varying substrate specificities and catalytic mechanisms, contributing to the diverse functions of the complex.

2. **RNA-binding proteins:** These proteins bind to RNA molecules, often with high specificity, facilitating the recruitment of endoribonucleases to their target transcripts. They can also act as adaptors, bridging the endoribonuclease to other cellular components involved in RNA processing or degradation.

3. **Scaffold proteins:** These proteins provide structural integrity to the complex, organizing the various components into a functional unit. They can also modulate the activity of the endoribonuclease, acting as regulators or activators.

4. **Other regulatory proteins:** The complex may include additional proteins that influence its activity or localization. These proteins can be involved in signal transduction pathways, mediating the response to specific stimuli or cellular stress.

5. **RNA substrates:** The complex acts on specific RNA molecules, including mRNAs, rRNAs, tRNAs, and non-coding RNAs. These substrates can be recognized by the complex through their specific sequences, secondary structures, or modifications.

The cellular component of endoribonuclease complexes can be further localized within the cell, depending on their function. For example, some complexes reside in the cytoplasm, participating in mRNA degradation and translational control, while others are found in the nucleus, involved in pre-mRNA processing and ribosome biogenesis. The precise composition and localization of the complex dictate its specific role in RNA metabolism.

The dynamic nature of endoribonuclease complexes allows for fine-tuning of RNA processing events, ensuring efficient and accurate gene expression in response to changing cellular needs. Their intricate organization and diverse functionalities make them essential players in maintaining cellular homeostasis.'
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Proteins (1)

Compounds (1)