ankyrin-1 complex

Definition

Target type: cellularcomponent

A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human. [PMID:35835865]

Ankyrin-1, also known as erythrocyte membrane protein band 2.1, is a large protein that plays a crucial role in linking the plasma membrane to the underlying cytoskeleton in various cell types. The ankyrin-1 complex is a multi-protein assembly that localizes to specialized membrane domains, primarily in erythrocytes, but also in neurons, muscle cells, and other tissues. The core of the ankyrin-1 complex comprises ankyrin-1 itself, which binds to the cytoplasmic domain of the integral membrane protein band 3, a transmembrane anion exchanger responsible for the transport of chloride and bicarbonate ions across the plasma membrane. This interaction is essential for maintaining the structural integrity of the erythrocyte membrane and for the efficient transport of these ions. Ankyrin-1 also interacts with spectrin, a long, flexible protein that forms a network underlying the plasma membrane. This interaction contributes to the formation of the erythrocyte cytoskeleton, providing structural support and flexibility to the cell. Additionally, ankyrin-1 can bind to other membrane proteins, including the sodium-potassium pump, the glucose transporter, and various signaling molecules. These interactions contribute to the organization and function of specific membrane domains. In summary, the cellular component of the ankyrin-1 complex is a multi-protein assembly that forms a scaffold at the plasma membrane. This scaffold links the membrane to the cytoskeleton, provides structural support, and organizes the distribution and function of specific membrane proteins. This complex plays a crucial role in maintaining the integrity and function of various cell types, particularly erythrocytes.'
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Proteins (1)

Compounds (1)