TEAD-YAP complex

Definition

Target type: cellularcomponent

A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP. [GOC:mah, PMID:11358867]

The TEAD-YAP complex, a key regulator of Hippo signaling pathway, resides primarily in the nucleus, where it interacts with DNA to control gene expression. The complex is a multi-protein assembly, with TEAD transcription factors acting as the DNA-binding component. YAP, a transcriptional co-activator, binds to TEAD, promoting its transcriptional activity. Other components like VGLL4, a TEAD cofactor, can also associate with the complex. This nuclear localization is essential for the complex to directly modulate gene transcription, driving processes like cell proliferation, growth, and organ size regulation. Notably, the complex can also be found in the cytoplasm under certain conditions, possibly interacting with other signaling pathways or undergoing post-translational modifications. The subcellular localization of TEAD-YAP complex is tightly regulated, dynamically shifting between the nucleus and cytoplasm based on cellular cues and signaling events. This dynamic localization further highlights the complexity of the complex's function and its multifaceted roles in regulating cell behavior.'
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Proteins (2)

Compounds (1)