Target type: cellularcomponent
A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. [PMID:26477565]
The MIB complex, also known as the mitochondrial import inner membrane (MIM) complex, is a multi-protein complex located in the inner mitochondrial membrane (IMM). It functions as a central gatekeeper for the import of proteins into the mitochondrial matrix. The complex is composed of four core subunits: TIM23, TIM17, TIM50, and TIM21. TIM23, a transmembrane protein, forms the central pore through which preproteins are translocated. TIM17 is also a transmembrane protein and forms a ring around the TIM23 channel, contributing to its stability. TIM50 acts as a receptor for preproteins containing an N-terminal mitochondrial targeting sequence (MTS). Finally, TIM21 is a small, membrane-associated protein that facilitates the release of preproteins from the TIM23 complex after they have been translocated into the matrix. The MIB complex is essential for mitochondrial function and its disruption can lead to various diseases, including mitochondrial myopathies and neurodegenerative disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Stress-70 protein, mitochondrial | A stress-70 protein, mitochondrial that is encoded in the genome of human. [PRO:DAN] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| (((4-nitrophenyl)amino)(2,2,4,4-tetramethyl thiochroman-6-yl)amino) methane-1-thione |