Target type: cellularcomponent
Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems]
Gemini of coiled bodies are nuclear structures found in eukaryotic cells. They are characterized by their unique morphology, appearing as two closely associated, spherical or ellipsoidal bodies. The core of Gemini is composed of a densely packed network of protein filaments, primarily consisting of the coiled-coil protein Smn (Survival of Motor Neuron). These filaments form a complex network that interacts with other nuclear proteins and RNA molecules. Gemini are often located near Cajal bodies, another type of nuclear structure, and they play a crucial role in the biogenesis of snRNPs (small nuclear ribonucleoproteins), essential components of the spliceosome. The specific role of Gemini in snRNP assembly is still under investigation, but it is believed that they provide a platform for the assembly and modification of snRNP components. Beyond snRNP biogenesis, Gemini are also implicated in other cellular processes, including RNA metabolism, transcription, and DNA repair. They are highly dynamic structures, and their size and number can vary depending on the cell type and its stage of development.'
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Protein | Definition | Taxonomy |
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Survival motor neuron protein | A survival motor neuron protein that is encoded in the genome of human. [PRO:DAN, UniProtKB:Q16637] | Homo sapiens (human) |
Survival motor neuron protein | A survival motor neuron protein that is encoded in the genome of human. [PRO:DAN, UniProtKB:Q16637] | Homo sapiens (human) |
Gem-associated protein 4 | A gem-associated protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P57678] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
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indoprofen | indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein. Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21) | gamma-lactam; isoindoles; monocarboxylic acid | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
1-[4-(4-bromophenyl)-2-thiazolyl]-4-piperidinecarboxamide | piperidinecarboxamide | ||
dehydrocurvularin |