central region of growth cone

Definition

Target type: cellularcomponent

The center of the migrating motile tip of a growing nerve cell axon or dendrite. [GOC:sl, PMID:16260607]

The central region of the growth cone, also known as the central domain, is a dynamic and complex structure crucial for guiding neuronal growth and establishing connections. It is characterized by a dense network of microtubules, which provide structural support and act as tracks for the transport of organelles and signaling molecules. The central region also contains a high concentration of actin filaments, which contribute to its dynamic shape and motility. This region is enriched in signaling molecules, including receptors, kinases, and GTPases, which mediate the integration of external cues and guide the growth cone's direction. The central region is also populated by a variety of other cellular components, including endoplasmic reticulum, Golgi apparatus, mitochondria, and vesicles. These organelles play critical roles in protein synthesis, modification, and trafficking, as well as in providing energy and regulating intracellular signaling. The central region of the growth cone is constantly adapting and responding to environmental cues, ensuring that the growing axon navigates its path towards its target. It is a highly dynamic and regulated environment, with a complex interplay of signaling pathways and cellular components, all working together to guide the growth cone and ensure proper neuronal development.'
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Proteins (1)

Compounds (2)