cation-transporting ATPase complex

Definition

Target type: cellularcomponent

Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:BHF]

The cation-transporting ATPase complex is a vital component of cellular membranes, playing a crucial role in maintaining ion gradients across the membrane. This complex is a multi-subunit structure composed of at least two distinct domains: the catalytic domain and the regulatory domain. The catalytic domain is responsible for the hydrolysis of ATP, providing the energy required for ion transport. The regulatory domain interacts with various intracellular signaling molecules, controlling the activity of the pump. The complex typically spans the cell membrane, possessing transmembrane domains that facilitate the movement of ions across the lipid bilayer. The cation-transporting ATPase complex is a dynamic entity, undergoing conformational changes during the transport cycle. These changes involve transitions between different states, each with distinct structural features and affinities for ions. The specific subunit composition and structural organization of the cation-transporting ATPase complex can vary depending on the type of cation transported, the cellular context, and the organism. However, the core function of ATP hydrolysis coupled to ion transport remains constant. This complex is essential for maintaining cellular homeostasis, regulating cell volume, and driving numerous physiological processes, including nerve impulse transmission, muscle contraction, and nutrient uptake.'
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Proteins (1)

Compounds (9)