Page last updated: 2024-10-24

cation-transporting ATPase complex

Definition

Target type: cellularcomponent

Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:BHF]

The cation-transporting ATPase complex is a vital component of cellular membranes, playing a crucial role in maintaining ion gradients across the membrane. This complex is a multi-subunit structure composed of at least two distinct domains: the catalytic domain and the regulatory domain. The catalytic domain is responsible for the hydrolysis of ATP, providing the energy required for ion transport. The regulatory domain interacts with various intracellular signaling molecules, controlling the activity of the pump. The complex typically spans the cell membrane, possessing transmembrane domains that facilitate the movement of ions across the lipid bilayer. The cation-transporting ATPase complex is a dynamic entity, undergoing conformational changes during the transport cycle. These changes involve transitions between different states, each with distinct structural features and affinities for ions. The specific subunit composition and structural organization of the cation-transporting ATPase complex can vary depending on the type of cation transported, the cellular context, and the organism. However, the core function of ATP hydrolysis coupled to ion transport remains constant. This complex is essential for maintaining cellular homeostasis, regulating cell volume, and driving numerous physiological processes, including nerve impulse transmission, muscle contraction, and nutrient uptake.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sodium/hydrogen exchanger 1A sodium/hydrogen exchanger 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P19634]Homo sapiens (human)

Compounds (9)

CompoundDefinitionClassesRoles
ethylisopropylamilorideethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group.

ethylisopropylamiloride: structure in first source
aromatic amine;
guanidines;
monocarboxylic acid amide;
organochlorine compound;
pyrazines;
tertiary amino compound
anti-arrhythmia drug;
neuroprotective agent;
sodium channel blocker
benzotriazolebenzotriazole : The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring.

benzotriazole: inhibitor of atmospheric metal corrosion; also component of motion picture film & Neva brake fluid
benzotriazolesenvironmental contaminant;
xenobiotic
amilorideamiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.

Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
aromatic amine;
guanidines;
organochlorine compound;
pyrazines
diuretic;
sodium channel blocker
amiloride hydrochlorideamiloride hydrochloride dihydrate : A hydrate that is the dihydrate of amiloride hydrochloride.hydratediuretic;
sodium channel blocker
cariporidecariporide: a selective sodium-hydrogen exchange subtype 1 inhibitor; structure in first source
eniporideeniporide: inhibits NHE-1 isoform; structure in first source
zoniporidezoniporide: inhibits sodium-hydrogen exchanger isoform-1 (NHE-1)
sabiporidesabiporide: a NHE-1 inhibitor and a cardioprotective agent; structure in first source
(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine(5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl)guanidine: KR-32570 possesses potent cardioprotective effects in perfused rat hearts, and its effects may be mediated by inhibition of NHE-1, preservation of high-energy phosphates, and inhibition of lipid peroxidation