Target type: cellularcomponent
A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. [GOC:mah, PMID:20516061]
The PTW/PP1 phosphatase complex is a multi-protein complex involved in regulating various cellular processes. Its cellular component encompasses a diverse group of proteins, each contributing to the complex's overall function. The core of the complex comprises the catalytic subunit, PP1, which possesses phosphatase activity. PP1's activity is tightly regulated by its interactions with various regulatory subunits, including PTW, which serves as a scaffold protein. PTW binds to PP1 through its C-terminal domain and also interacts with other proteins, such as the cytoskeleton. This interaction with the cytoskeleton suggests a role for the PTW/PP1 complex in regulating cytoskeletal dynamics. Furthermore, PTW interacts with other regulatory subunits of PP1, including Gu003csubu003eMu003c/subu003e and MYPT1. These interactions further regulate the activity and localization of the complex. The cellular localization of the PTW/PP1 complex is dynamic and varies depending on the cellular context and the specific regulatory subunits associated with it. The complex can be found in the cytoplasm, nucleus, and associated with various cellular structures, including the cytoskeleton and organelles. The specific localization of the complex is critical for its function in regulating different cellular processes, such as glycogen metabolism, muscle contraction, and cell signaling. The diversity of the PTW/PP1 complex's components and its dynamic localization contribute to its versatile regulatory role in a wide range of cellular processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | A serine/threonine-protein phosphatase PP1-gamma catalytic subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36873] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| cantharidin | cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A. Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally. | cyclic dicarboxylic anhydride; monoterpenoid | EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; herbicide |
| cyanoginosin lr | cyanoginosin LR: cyclic heptapeptide from cyanobacterium Microcystis aeruginosa microcystin-LR : A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. | microcystin | bacterial metabolite; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; environmental contaminant; xenobiotic |
| okadaic acid | polycyclic ether | calcium ionophore; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; marine metabolite | |
| calyculin a | calyculin A: RN given refers to (5S-(5alpha(2R*(1S*,3S*,4S*,5R*,6R*,7E,9E,11E,13Z),3R*),7beta(E(S*)),*beta,9alpha))-isomer |