Target type: cellularcomponent
A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054]
The catenin-TCF7L2 complex is a key component of the Wnt signaling pathway, which plays a crucial role in embryonic development, cell proliferation, and tissue homeostasis. The complex is formed by the interaction of β-catenin, a protein that acts as a bridge between cell adhesion junctions and the transcriptional machinery, and TCF7L2, a transcription factor that regulates gene expression.
The cellular component of the catenin-TCF7L2 complex is localized to the nucleus, where it interacts with DNA to regulate gene transcription. β-catenin, when not bound to TCF7L2, is primarily located at cell junctions, where it interacts with cadherin proteins to maintain cell adhesion. However, upon activation of the Wnt signaling pathway, β-catenin is released from the junctions and translocates to the nucleus, where it forms a complex with TCF7L2.
The formation of the catenin-TCF7L2 complex is regulated by a complex interplay of proteins, including the Wnt proteins, frizzled receptors, dishevelled proteins, and glycogen synthase kinase 3β (GSK3β). When Wnt proteins bind to frizzled receptors, they trigger a cascade of events that ultimately leads to the inhibition of GSK3β. This inhibition prevents the phosphorylation of β-catenin, which normally targets it for degradation. As a result, β-catenin accumulates in the cytoplasm and translocates to the nucleus, where it forms a complex with TCF7L2.
The catenin-TCF7L2 complex then binds to specific DNA sequences known as Wnt-responsive elements (WREs), located in the promoters of target genes. This binding activates gene transcription, leading to the expression of various proteins that promote cell proliferation, survival, and differentiation. The Wnt signaling pathway, and consequently the catenin-TCF7L2 complex, is tightly regulated to ensure proper cell development and function. Dysregulation of this pathway can lead to various diseases, including cancer.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Transcription factor 7-like 2 | A transcription factor 7-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQB0] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |