Kv4.2-KChIP2 channel complex

Definition

Target type: cellularcomponent

A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2. [PMID:15356203]

The Kv4.2-KChIP2 channel complex is a tetrameric protein complex localized to the plasma membrane of neurons and other excitable cells. It plays a crucial role in regulating neuronal excitability by mediating a transient outward potassium current (IKr). The complex is formed by four Kv4.2 α subunits, which form the pore through which potassium ions flow, and four KChIP2 β subunits, which regulate the trafficking, stability, and gating properties of the channel.

The Kv4.2 α subunit is a transmembrane protein with six transmembrane domains (S1-S6). The S4 segment, which is located between the third and fourth transmembrane domains, contains positively charged amino acids that sense changes in membrane potential and trigger channel opening. The S5 and S6 segments form the pore loop, which lines the ion conduction pathway.

The KChIP2 β subunit is a cytoplasmic protein that interacts with the Kv4.2 α subunit through its N-terminal domain. KChIP2 has a PDZ domain, which binds to the C-terminal tail of the Kv4.2 subunit, and a coiled-coil domain, which mediates tetramerization.

The assembly of the Kv4.2-KChIP2 channel complex is a complex process that involves multiple steps. First, the Kv4.2 α subunits assemble into tetramers. Then, the KChIP2 β subunits bind to the Kv4.2 tetramers, stabilizing the complex and promoting its trafficking to the plasma membrane.

The cellular component of the Kv4.2-KChIP2 channel complex is the plasma membrane of neurons and other excitable cells. This localization is essential for the complex to perform its function in regulating neuronal excitability. The complex is concentrated at the axon initial segment, a specialized region of the axon where action potentials are initiated. This localization ensures that the complex can effectively regulate the generation of action potentials.

The Kv4.2-KChIP2 channel complex is a critical regulator of neuronal excitability. Its assembly and localization to the plasma membrane are essential for its function. Understanding the structure and function of this complex is important for developing new therapies for neurological disorders.'
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Proteins (1)

Compounds (1)