ciliary neurotrophic factor receptor complex

Definition

Target type: cellularcomponent

A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR. [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266]

The ciliary neurotrophic factor receptor (CNTFR) complex is a multimeric receptor complex that plays a crucial role in the development and maintenance of the nervous system. The complex is comprised of three distinct protein subunits: CNTFRα, gp130, and LIFRβ. CNTFRα acts as the primary ligand binding subunit for CNTF. Upon CNTF binding, CNTFRα recruits the signaling subunits gp130 and LIFRβ, forming a heterotrimeric complex. This complex initiates downstream signaling pathways, primarily through the activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, leading to the regulation of various cellular processes.

The cellular component of the CNTFR complex resides in the plasma membrane of target cells. This membrane localization is essential for the complex to interact with CNTF and initiate its signaling cascade. The CNTFR complex is typically found in neuronal cells, glial cells, and other cell types involved in nervous system development and function. Its specific localization and interaction with other cellular components contribute to its role in regulating neuronal survival, differentiation, and plasticity.'
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Proteins (1)

Compounds (2)