microspike

Definition

Target type: cellularcomponent

A dynamic, actin-rich projection extending from the surface of a migrating animal cell. [PMID:11429692, PMID:12153987, PMID:19095735]

Microspikes are small, finger-like protrusions of the plasma membrane that extend from the cell surface. They are typically 1-2 µm in length and 0.1-0.2 µm in diameter. Microspikes are found in a variety of cell types, including epithelial cells, fibroblasts, and neurons. They are thought to play a role in cell adhesion, migration, and signal transduction. The core of a microspike is composed of actin filaments, which are arranged in a parallel bundle. This bundle is anchored to the plasma membrane by a protein called ezrin. The microspike also contains a variety of other proteins, including myosin, talin, vinculin, and α-actinin. These proteins help to regulate the assembly and disassembly of the microspike, as well as its interaction with the extracellular matrix. Microspikes are highly dynamic structures, and they can extend and retract rapidly in response to changes in the cell's environment. They are thought to be involved in a variety of cellular processes, including cell migration, wound healing, and immune responses.'
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Proteins (1)

Compounds (1)