hyaluranon cable

Definition

Target type: cellularcomponent

A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. [GOC:yaf, PMID:16900089]

Hyaluronan cables are a specialized extracellular matrix structure found in various tissues, particularly in connective tissues like cartilage, tendons, and skin. They are primarily composed of hyaluronan, a large, unbranched polysaccharide, and associated proteins. The cellular component of hyaluronan cables is less defined compared to the matrix component, but it involves several key cell types and their interactions.

- **Fibroblasts:** These cells are the primary producers of hyaluronan and other extracellular matrix components. They synthesize and secrete hyaluronan into the extracellular space, contributing to the formation of the cable structure.
- **Chondrocytes:** In cartilage, chondrocytes are responsible for maintaining the integrity of the hyaluronan cable network. They synthesize and degrade hyaluronan, regulating its size and density within the cartilage matrix.
- **Other Cell Types:** Other cells may also contribute to the cellular component of hyaluronan cables, depending on the specific tissue. For example, in tendons, tenocytes are involved in the production and organization of hyaluronan within the tendon matrix.

The interaction between these cell types and the hyaluronan matrix is crucial for the formation and function of hyaluronan cables. The cables provide structural support, resistance to compression, and facilitate cell communication within the tissue. They also act as a reservoir for water and other nutrients, contributing to the overall homeostasis of the extracellular environment.'
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Proteins (1)

Compounds (4)