SPOTS complex

Definition

Target type: cellularcomponent

A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. [PMID:20182505]

The SPOTS complex is a multiprotein complex involved in the assembly and stability of the kinetochore, a protein structure that attaches chromosomes to microtubules during cell division. The cellular component of the SPOTS complex is composed of several proteins, including:

- **Spindly:** This protein acts as a scaffold and is essential for the assembly of the SPOTS complex. It interacts with several other components of the complex, including the Ska proteins.
- **Ska1, Ska2, Ska3:** These proteins are also scaffold proteins and contribute to the structural integrity of the SPOTS complex. They interact with Spindly and other components, including the CENP-T/W complex.
- **CENP-T/W complex:** This complex is a component of the inner kinetochore and interacts with the SPOTS complex through Ska proteins. It plays a role in connecting the SPOTS complex to the CENP-A nucleosome, the specialized histone that marks the centromere region of chromosomes.
- **MIS12 complex:** This complex is also a component of the inner kinetochore and interacts with the SPOTS complex through Ska proteins. It helps to link the SPOTS complex to the microtubule-binding outer kinetochore.

The SPOTS complex is located at the centromere of chromosomes and is essential for proper chromosome segregation during cell division. Its components work together to ensure that chromosomes are correctly attached to microtubules and that they are properly separated during mitosis and meiosis.'
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Proteins (1)

Compounds (1)