piccolo histone acetyltransferase complex
Definition
Target type: cellularcomponent
A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. [GOC:rb, PMID:12782659, PMID:15964809]
The piccolo histone acetyltransferase (HAT) complex is a multi-protein complex involved in the acetylation of histones, which are proteins that package and organize DNA in the nucleus. This complex plays a critical role in gene regulation, chromatin remodeling, and DNA repair. The complex is characterized by its association with the piccolo protein, a scaffolding protein involved in the formation of presynaptic active zones at neuronal synapses.
The cellular component of the piccolo HAT complex can be described as follows:
- **Piccolo:** A scaffolding protein that provides structural support to the complex. It binds to other components of the complex and anchors it to the presynaptic active zone.
- **Histone acetyltransferases (HATs):** Enzymes that catalyze the transfer of acetyl groups from acetyl-CoA to lysine residues on histone tails. The specific HATs present in the piccolo HAT complex can vary depending on the cell type and developmental stage. Some common HATs found in this complex include GCN5, PCAF, and Tip60.
- **Other associated proteins:** In addition to piccolo and HATs, the complex may also include other proteins that regulate its activity or mediate its interactions with other cellular components. These proteins can include, but are not limited to, chromatin remodeling enzymes, DNA repair factors, and transcription factors.
The piccolo HAT complex is typically localized to the presynaptic active zone, where it contributes to the regulation of synaptic transmission. It is believed to regulate gene expression in neurons by modifying the accessibility of DNA to transcription factors. The complex may also play a role in other cellular processes, such as DNA repair and cell cycle regulation.
The precise composition and function of the piccolo HAT complex can vary depending on the cell type and developmental stage. Further research is needed to fully understand the molecular mechanisms underlying its activity and its role in neuronal function.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Histone acetyltransferase KAT5 | A histone acetyltransferase KAT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92993] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| epigallocatechin gallate | (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis) | flavans; gallate ester; polyphenol | antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite |
| coenzyme a | adenosine 3',5'-bisphosphate | coenzyme; Escherichia coli metabolite; mouse metabolite | |
| anacardic acid | anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor | hydroxy monocarboxylic acid; hydroxybenzoic acid | anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite |
| 2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid | hydroxybenzoic acid | ||
| 1,2-bis(isothiazol-5-yl)disulfane | 1,2-bis(isothiazol-5-yl)disulfane: structure in first source |