CBM complex

Definition

Target type: cellularcomponent

A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. [PMID:12909454, PMID:30467369]

The CBM complex, also known as the CBC complex, is a multiprotein complex that plays a crucial role in the regulation of cellular processes, including cell cycle progression, DNA replication, and transcription. It is composed of several subunits, each with its own distinct function.

The cellular component of the CBM complex can be described as follows:

* **Nuclear localization:** The CBM complex is predominantly localized to the nucleus, specifically within the nucleoplasm.
* **Interaction with chromatin:** The complex interacts directly with chromatin, the complex of DNA and proteins that makes up chromosomes. This interaction is essential for its regulatory functions.
* **Association with specific DNA sequences:** The CBM complex exhibits affinity for specific DNA sequences, including those found in promoters and regulatory regions of genes.
* **Formation of a multiprotein scaffold:** The subunits of the CBM complex assemble into a highly organized structure, creating a scaffold that facilitates interactions with other proteins and DNA.
* **Dynamic nature:** The composition and localization of the CBM complex can change depending on the cellular context and specific regulatory requirements.

The precise cellular component of the CBM complex can vary depending on the specific cell type and developmental stage. However, its nuclear localization, interaction with chromatin, and ability to assemble into a multiprotein scaffold are key features that contribute to its diverse functions in the regulation of cellular processes.'
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Proteins (1)

Compounds (3)