integrator complex

Definition

Target type: cellularcomponent

A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. [PMID:16239144]

The integrator complex is a multi-protein complex that plays a crucial role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome. It is located within the nucleus, specifically in the Cajal bodies, which are subnuclear structures enriched in snRNPs. The integrator complex is composed of multiple subunits, each with a distinct function in the assembly and processing of snRNPs. These subunits include: \\n\\n* **INTs (Integrator subunits):** These are the core components of the complex and are responsible for binding to the nascent snRNA transcripts and mediating their 3' end processing. INTs work in concert with other proteins, such as the 3' end processing factors, to ensure accurate and efficient cleavage and polyadenylation of snRNAs. \\n\\n* **Other associated proteins:** In addition to the INTs, the integrator complex also contains other proteins that contribute to its functionality. These include proteins involved in: \\n * **Chromatin remodeling:** Some proteins associated with the integrator complex assist in the regulation of chromatin structure, influencing snRNA gene transcription and accessibility. \\n * **RNA processing and transport:** Certain proteins facilitate the proper folding and transport of snRNPs after their assembly. \\n\\nThe integrator complex is essential for proper spliceosome assembly and function. Its role in snRNP biogenesis is critical for accurate splicing of pre-mRNAs, a process that is essential for the production of functional proteins. Mutations or dysregulation of the integrator complex can lead to a variety of human diseases, including developmental disorders and cancer.'
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Proteins (1)

Compounds (3)